Sharira Rachana, the Ayurvedic understanding of structural anatomy, presents the human body as an interconnected entity closely related to the natural environment. Ayurveda explains this relationship through fundamental concepts such as Panchamahabhuta, Dosha, Dhatu, Mala and Marma. The present narrative review explores the relationship between Panchamahabhuta and Sharira Rachana and examines how nature-oriented principles can contribute to a meaningful understanding of human anatomy. Classical Ayurvedic sources, particularly Charaka Samhita, Sushruta Samhita and Ashtanga Hridaya, together with selected secondary literature, were reviewed thematically. The review identifies Panchamahabhuta as a conceptual foundation for understanding the qualities and organization of the body, while Dhatu provides a framework for tissue organization and nourishment. Marma demonstrates the clinical relationship between anatomical structures and vital functions. The review further highlights the relevance of environmental adaptation and natural rhythms through Ayurvedic concepts such as Dinacharya and Ritucharya. Integration of these classical perspectives with modern anatomical education may support conceptual learning, provided that classical concepts are not assumed to have exact one-to-one equivalents in contemporary anatomy. A nature-based approach can therefore enrich Rachana Sharir education by encouraging learners to perceive the human body as an organized, adaptive and interconnected living system.